Located in central Oklahoma, Seminole is approximately 50 miles east southeast from Oklahoma City. The Seminole Nation, one of the 5 Civilized Tribes, was moved to Indian Territory and located with the Creek Nation. Eventually, the Seminoles were given their own territory, and when Oklahoma became a state in 1907, the territories of the Seminole Nation became Seminole County.

In the mid-1920's, Seminole was home of one of the last oil booms, with tens of thousands of oilfield workers temporarily residing in Seminole. Oil production in the Greater Seminole Oil Field reached a peak of over half a million barrels on July 30, 1927. High production rates in the Seminole field forced the first industry price regulation.

Wtih a population of 6,899 (2000 Census), Seminole today is home to the Seminole Nation, Seminole State College, the Jasmine Moran Childrens' Museum, as well as Enviro Systems.